The growing interest in berberine reflects a significant trend in health and nutrition towards incorporating natural supplements for managing and enhancing health, particularly in areas like metabolic syndrome, diabetes, and cardiovascular health. This trend signifies an increasing consumer and scientific interest in the potential of natural compounds to offer health benefits, often with fewer side effects compared to conventional pharmaceuticals. The popularity of berberine surged due to social media influence, particularly exposure on Tik Tok. It demonstrates consumers the shift towards more holistic, integrative approaches to health, where traditional herbal remedies are re-evaluated and integrated into modern medical practices. It also highlights the expanding role of dietary supplements in preventive health and the management of chronic conditions. However, this trend also brings to light the need for more rigorous scientific research to validate the efficacy and safety of natural supplements like berberine, ensuring they are used appropriately and effectively. Overall, the interest in berberine is indicative of a broader movement in health and nutrition towards embracing a diverse array of therapeutic options, blending traditional herbal knowledge with contemporary scientific research.